About ProgEuro

There are significant challenges in the four research areas of:

  • Developmental origins of health and disease. The wide use of growth variables as the indicators of foetal environment remains the major methodological limitation. And no research in humans has been able to examine the biomarkers at different programming stages from exposure itself to disease in one single study.
  • Stress. It remains difficult to assess stress and to obtain data on long-term health in a large study. The biological programming effects of prenatal stress need to be elucidated.
  • Bereavement. There is a significant knowledge gap in health of children bereaved by the death of a close relative.
  • Register-based research. It is necessary to combine the multinational data to understand the aetiology and the impact of rare disease and the effects of certain risk factors. But such attempts have been facing many obstacles.

These challenges may lead to difficulties and uncertainties for the study. On the other hand, however, they may prove to be the source of new scientific insights, hypotheses, and theories. The project is establishing an extremely large-scale study with long-term combined data. The data on long-term exposure and health in this study is available only in North European countries where detailed information on each citizen over decades of time is entered into the national registration systems. Further, linkage to data in a birth cohort with biological measurements will further strengthen the study.